A Comparative Study of the Properties of Polar and Nonpolar Solvent/Solute/Polystyrene Solutions in Microwave Fields Via Molecular Dynamics

The influence of an applied microwave field on the dynamics of methylamine-dichloromethane (DCM) mixtures bound within atactic polystyrene (a-PS) over a range of polymer densities from 30 to 94 wt % polymer was examined using atomistic molecular dynamics simulations. This study is an extension of previous studies on methylamine transport in relatively polar polystyrene solutions of methanol and dimethylformamide [M. J. Purdue et al., J. Chem. Phys. 124, 204904 (2006)]. A direct comparison is made across the three types of polystyrene solutions. Consideration is given to both solvent and reagent transport within the polymer solutions under zero-field conditions and in an external electromagnetic field in the canonical ensemble (NVT) at 298.0 K. Various frequencies up to 104 GHz and a rms electric field intensity of 0.1 V/Å were applied. The simulation studies were validated by comparison of the simulated zero-field self-diffusion coefficients of DCM in a-PS with those obtained using pulsed-gradient spin-echo NMR spectrometry. Athermal effects of microwave fields on solute transport behavior within polymer solutions are discussed

Genetic heterogeneity of white-tailed deer: management lessons from a long-term study

Genetic data from a long-term (16-year) study of white-tailed deer (Odocoileus virginianus) on the U.S. Department of Energy\u27s Savannah River Site (SRS) were examined to evaluate spatial and temporal genetic heterogeneity in this species. Based on our analyses of the long-term data set, three major findings emerged, all of which have important implications for management of white-tailed deer: (1) There exists significant spatial genetic heterogeneity in white-tailed deer based on analyses of allozyme frequencies and mtDNA haplotypes. This heterogeneity exists on a much smaller spatial scale than would be expected for such a large and potentially mobile species as 0. virginianus. (2) The genetic structure of white-tailed deer at SRS is temporally dynamic and significant heterogeneity exists within demographic units such as age and sex classes. (3) Levels of genetic variation, as measured by multilocus heterozygosity, are frequently correlated to characteristics that are important determinants of ecological function in white-tailed deer populations. These findings are evaluated in the context of a general management model for 0. virginianus that is also applicable to other wildlife species

Molecular Dynamics of Polystyrene Solutions in Microwave Fields

Equilibrium and nonequilibrium molecular dynamics simulation techniques were used to assess the influence of an applied microwave field on the dynamics of methylamine-methanol and methylamine-dimethylformamide (DMF) solutions bound within atactic polystyrene over a range of polymer densities from 35 to 96 wt % polymer. Atomistically detailed systems were studied, ranging from 3000 to 10 644 particles, using previously established potential models. Structural and dynamical properties were determined in the canonical (NVT) ensemble at 298 K. The simulated DMF self-diffusion coefficients in polystyrene solutions were compared with the zero-field experimental results established with pulsed-gradient spin-echo NMR spectrometry. A simulated external microwave field, with a rms electric field intensity of 0.1 V/Å, was applied to these systems and the simulated dynamical results over field frequencies up to 104 GHz were compared with the zero-field values. Simulated evidence of athermal effects on the diffusive characteristics of these mixtures is reported

A quasilocal calculation of tidal heating

We present a method for computing the flux of energy through a closed surface containing a gravitating system. This method, which is based on the quasilocal formalism of Brown and York, is illustrated by two applications: a calculation of (i) the energy flux, via gravitational waves, through a surface near infinity and (ii) the tidal heating in the local asymptotic frame of a body interacting with an external tidal field. The second application represents the first use of the quasilocal formalism to study a non-stationary spacetime and shows how such methods can be used to study tidal effects in isolated gravitating systems.Comment: REVTex, 4 pages, 1 typo fixed, standard sign convention adopted for the Newtonian potential, a couple of lines added to the discussion of gauge dependent term

Ancient agriculture in Southeast Arabia: A three thousand year record of runoff farming from central Oman (Rustaq)

Runoff farming is a key hydro-agricultural strategy that has proven efficient in arid areas. Research in Arabia on the function, development, maintenance, durability and abandonment of this technology is scarce. A multiproxy investigation (cartography, sedimentology, pedology, geochemistry, paleo-ecology and chronology) was conducted on a recently abandoned terraced area in Rustaq, Northern Oman. The aim was to characterize the formation, function and management of this runoff system and the driving factors behind its success. Cycles of cultivation were identified during the Iron Age II/III periods (specifically 750–450 BCE), the Early Pre-Islamic Period (PIR) (specifically 350–200 BCE), the Early and Middle Islamic periods (specifically 8–10th C CE, 13th-14th C CE) and the late Islamic period (specifically 17th C CE and later). This expansion and perenniality was possible thanks to: 1- available water (local to micro-regional orogenic precipitation despite a regional aridification during these periods); 2- suitable soils (weathered geological outcrops, probable aeolian /dust particles); 3- a system of production combining crops and husbandry; 4- a progressive increase in agricultural specialization (crops grown and techniques) in parallel with a diversification in hydraulic technology. These results are to some degree in accordance with known phases of settlement intensification and economic growth, but also reveal the persistence of small-scale rural livelihoods during periods of harsh conditions for which archaeological traces are very scarce

The future of social is personal: the potential of the personal data store

This chapter argues that technical architectures that facilitate the longitudinal, decentralised and individual-centric personal collection and curation of data will be an important, but partial, response to the pressing problem of the autonomy of the data subject, and the asymmetry of power between the subject and large scale service providers/data consumers. Towards framing the scope and role of such Personal Data Stores (PDSes), the legalistic notion of personal data is examined, and it is argued that a more inclusive, intuitive notion expresses more accurately what individuals require in order to preserve their autonomy in a data-driven world of large aggregators. Six challenges towards realising the PDS vision are set out: the requirement to store data for long periods; the difficulties of managing data for individuals; the need to reconsider the regulatory basis for third-party access to data; the need to comply with international data handling standards; the need to integrate privacy-enhancing technologies; and the need to future-proof data gathering against the evolution of social norms. The open experimental PDS platform INDX is introduced and described, as a means of beginning to address at least some of these six challenges

Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy.

INTRODUCTION: The purpose of the present manuscript is to test the hypothesis that arthrotropic localization and synovial cell internalization account for the unique capacity of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-dexamethasone conjugate (P-Dex, a macromolecular prodrug of dexamethasone) to induce sustained amelioration of joint inflammation and inhibition of tissue damage in an animal model of inflammatory arthritis. METHODS: Rats with adjuvant-induced arthritis (AA) were treated with P-Dex, free dexamethasone, saline or HPMA homopolymer. To define the biodistribution of P-Dex, conjugates with different imaging labels were given to AA rats and analyzed. Isolated joint tissues were evaluated by fluorescence-activated cell sorting (FACS) and immunohistochemical staining. Cellular uptake of P-Dex and its effects on apoptosis and production of proinflammatory cytokines were examined using human monocyte-macrophages and fibroblasts. RESULTS: A single systemic administration of P-Dex completely suppressed AA for \u3e20 days. Magnetic resonance imaging demonstrated higher HPMA copolymer influx into the inflamed joints than the normal joints. Immunohistochemistry and FACS analyses of arthritic joints revealed extensive uptake of the polymer conjugate by synovial fibroblasts and myeloid lineage cells. The capacity of P-Dex to suppress inflammation was confirmed in monocyte-macrophage cultures in which P-Dex treatment resulted in suppression of lipopolysaccharide-induced IL-6 and TNFα release. Similarly, TNFα-induced expression of matrix metalloproteinases (MMP1 and MMP3) in synovial fibroblasts from a rheumatoid arthritis patient was suppressed by P-Dex. P-Dex showed no detectable effect on monocyte apoptosis. CONCLUSIONS: P-Dex provides superior and sustained amelioration of AA compared with an equivalent dose of free dexamethasone. The arthrotropism and local retention of P-Dex is attributed to the enhanced vascular permeability in arthritic joints and the internalization of P-Dex by synovial cells. The uptake and processing of P-Dex by macrophages and fibroblasts, and downregulation of proinflammatory mediators, provides an explanation for the sustained anti-inflammatory efficacy of P-Dex in this model of inflammatory arthritis

Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy

INTRODUCTION: The purpose of the present manuscript is to test the hypothesis that arthrotropic localization and synovial cell internalization account for the unique capacity of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-dexamethasone conjugate (P-Dex, a macromolecular prodrug of dexamethasone) to induce sustained amelioration of joint inflammation and inhibition of tissue damage in an animal model of inflammatory arthritis. METHODS: Rats with adjuvant-induced arthritis (AA) were treated with P-Dex, free dexamethasone, saline or HPMA homopolymer. To define the biodistribution of P-Dex, conjugates with different imaging labels were given to AA rats and analyzed. Isolated joint tissues were evaluated by fluorescence-activated cell sorting (FACS) and immunohistochemical staining. Cellular uptake of P-Dex and its effects on apoptosis and production of proinflammatory cytokines were examined using human monocyte-macrophages and fibroblasts. RESULTS: A single systemic administration of P-Dex completely suppressed AA for \u3e20 days. Magnetic resonance imaging demonstrated higher HPMA copolymer influx into the inflamed joints than the normal joints. Immunohistochemistry and FACS analyses of arthritic joints revealed extensive uptake of the polymer conjugate by synovial fibroblasts and myeloid lineage cells. The capacity of P-Dex to suppress inflammation was confirmed in monocyte-macrophage cultures in which P-Dex treatment resulted in suppression of lipopolysaccharide-induced IL-6 and TNFα release. Similarly, TNFα-induced expression of matrix metalloproteinases (MMP1 and MMP3) in synovial fibroblasts from a rheumatoid arthritis patient was suppressed by P-Dex. P-Dex showed no detectable effect on monocyte apoptosis. CONCLUSIONS: P-Dex provides superior and sustained amelioration of AA compared with an equivalent dose of free dexamethasone. The arthrotropism and local retention of P-Dex is attributed to the enhanced vascular permeability in arthritic joints and the internalization of P-Dex by synovial cells. The uptake and processing of P-Dex by macrophages and fibroblasts, and downregulation of proinflammatory mediators, provides an explanation for the sustained anti-inflammatory efficacy of P-Dex in this model of inflammatory arthritis

Steel Bridge Coating Evaluation and Rating Criteria

SPR-4632The aim of the study is to gather information on three topics: (1) the evaluation and rating of steel bridge protective coatings, (2) coating systems used by various states throughout the United States, and (3) maintenance painting procedures employed by various state department of transportation agencies (DOTs). First, it was found that most state DOTs use either an Element Level type rating of the coating system or a 9\u20130 NBI type rating; many state DOTs use both methodologies, with one used for state bridges and the other for local bridges. Second, for coating systems, it was found that there is a great deal of uniformity of the steel bridge coating systems used in the United States, with three-coat paint systems being the most common. Third, it is believed that maintenance painting can extend the useful life of bridge coatings. However, many state DOTs report that the cost of maintenance painting has increased due to many factors that involve available personnel, proper training, and increased regulations on the removal and application of steel bridge coatings. Consequently, many DOTs no longer perform maintenance painting, other than emergency repairs, and simply wait until the entire bridge needs to be re-coated and contract the work out. Lastly, an NBI 9\u20130 type rating procedure for steel bridge coatings is proposed for possible consideration and implementation by INDOT